סמינר מחקר בחוג להנדסה ביו רפואית

מאיה ברנס-זאבי, תלמידת המחלקה לתואר שני תרצה בנושא:

Novel Drug-Eluting Soy Protein Films for Wound Healing Applications

Soy protein has advantages over various types of natural proteins employed for biomedical applications due to its low price, non-animal origin and relatively long storage time and stability. In the current study soy protein isolate (SPI) was investigated as a matrix for wound dressing applications. Several drugs (gentamicin, clindamycin, and bupivacain) were incorporated into the matrix for local controlled release. Aqueous solutions were casted into homogeneous films that combined high tensile strength and Young’s modulus with the desired ductility. SPI films were tested for relevant physical properties and drug release profiles. The gentamicin release profile exhibited a moderate burst effect followed by a decreasing release rate which was maintained for at least 4 weeks; while the rest of the release profiles exhibited a burst effect of about 60%-70% and a total drug release of 2 days. The research yielded SPI wound dressings with the desired mechanical and physical properties and drug release behavior to protect against bacterial infection. These unique structures are thus potentially useful as burn and ulcer dressings.

העבודה נעשתה בהנחיית פרופ' מיטל זילברמן, המחלקה להנדסה ביו-רפואית, אוניברסיטת תל-אביב.